New methodology toward chiral, non-racemic 2,5-cis-substituted piperidines via Suzuki cross-coupling

Article abstract of DOI:10.1021/ol061415d

1,2,3,4-Tetrahydropyridines were halogenated upon treatment with iodine to obtain the desired cross-coupling precursors. Diastereoselective hydrogenation of Suzuki cross-coupling adducts allowed the facile asymmetric synthesis of 2,5-cis-substituted piper