Journal of Medicinal Chemistry p. 1416 - 1421 (1984)
Update date:2022-08-03
Topics:
Shealy, Y. Fulmer
O'Dell, C. Allen
Shannon, W. M.
Arnett, Gussie
(+/-)-(1α,2β,4α)-4-<(2,5-Diamino-6-chloro-4-pyrimidinyl)amino>-2-hydroxycyclopentanemethanol (9) was synthesized by beginning with 2-amino-4,6-dichloropyrimidine and (+/-)-(1α,2β,4α)-4-amino-2-hydroxycyclopentanemethanol, preparing the 5-<(4-chlorophenyl)azo> derivative of the resulting pyrimidine, and reducing the azo derivative.The carbocyclic analogue of 2-amino-6-chloropurine 2'-deoxyribofuranoside (10) was prepared from 9 and triethyl orthoformate, and the analogous 8-azapurine (11) was obtained by diazotizing 9.From 10 or 11, the carbocyclic analogues of 2'-deoxyguanosine, 2'-deoxythioguanosine, 2,6-diaminopurine 2'-deoxyribofuranoside, 2'-deoxy-8-azaguanosine, and 2,6-diamino-8-azapurine 2'-deoxyribofuranoside were prepared.All of these 2'-deoxyribofuranoside analogues were active against herpes simplex virus (types 1 and 2) replicating in cells in culture; some demonstrated potent activity.
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