Synthesis of bicyclic molecular scaffolds (BTAa): An investigation towards new selective MMP-12 inhibitors

DOI: 10.1016/j.bmc.2006.07.028

Source and publish data:

Bioorganic and Medicinal Chemistry p. 7392 - 7403 (2006)

Update date:2022-08-05

Topics:

Authors:

Mannino, Claudia

Nievo, Marco

Machetti, Fabrizio

Papakyriakou, Athanasios

Calderone, Vito

Fragai, Marco

Guarna, Antonio

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Article abstract of DOI:10.1016/j.bmc.2006.07.028

Starting from 3-aza-6,8-dioxa-bicyclo[3.2.1]octane scaffold (BTAa) a virtual library of molecules was generated and screened in silico against the crystal structure of the Human Macrophage Metalloelastase (MMP-12). The molecules obtaining high score were

Full text of DOI:10.1016/j.bmc.2006.07.028

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Product name:6,8-Dioxa-3-azabicyclo[3.2.1]octane-7-carboxamide, N-([1,1'-biphenyl]-4-ylmethyl)-3-(phenylmethyl)-, (1S,5S,7R)-

Cas No:914076-03-2

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