Diastereoselective synthesis of highly constrained spiro-β-lactams by the staudinger reaction using an unsymmetrical bicyclic ketene

DOI: 10.1002/ejoc.200700260

Source and publish data:

European Journal of Organic Chemistry p. 4594 - 4599 (2007)

Update date:2022-08-02

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Authors:

Trabocchi, Andrea

Lalli, Claudia

Guarna, Francesco

Guarna, Antonio

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Article abstract of DOI:10.1002/ejoc.200700260

A rigid bicyclic ketene was used to generate highly constrained polycyclic spiro-β-lactams through the Staudinger reaction. Depending on the imine component, high diastereoselectivity was observed in the process, leading to mainly the cis diastereoisomer

Full text of DOI:10.1002/ejoc.200700260

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