Synthetic Communications p. 2667 - 2675 (2010)
Update date:2022-08-02
Topics:
Das, Biswanath
Sudhakar, Chithaluri
Srinivas, Yallamalla
Treatment of benzoin with an aldehyde and NH4OAc in polyethylene glycol (PEG-400) under reflux afforded a 5-substituted 2,3-diphenyl imidazole while the same reaction along with an additional aniline produced 5-substituted 1-aryl 2,3-diphenyl imidazole. No any catalyst or solvent was required to carry out this conversion, and the imidazoles were formed in excellent yields.
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