Tetrahedron p. 73 - 78 (1984)
Update date:2022-08-05
Topics:
Marugg, J. E.
Tromp, M.
Jhurani, P.
Hoyng, C. F.
Marel, G. A. van der
Boom, J. H. van
The application of the phosphorylating agent 2-chlorophenyl-o,o-bis-<1-benzotriazolyl>-phosphate (HOBT-approach) for the introduction of 3'-5'-phosphotriester linkages between a properly 5'-protected (4,4'-dimethoxytrityl) deoxy-nucleoside and a deoxy-nucleoside having free OH groups is described.In this way, all sixteen partially-protected DNA dimers having a free 3'-OH group have been synthesized.The dimers thus obtained have been applied, using the HOBT-approach, to the synthesis of the DNA fragments d-CGCGCG, d-CGTACG and d-ATATTAATAAC.
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