Journal of Medicinal Chemistry p. 1379 - 1388 (1984)
Update date:2022-08-03
Topics:
Walsh
Moran
Shamblee
Uwaydah
Welstead Jr.
Sancilio
Dannenburg
A series of substituted derivatives of 2-amino-3-benzoylphenylacetic acid (amfenac) has been synthesized and evaluated for antiinflammatory, analgesic, and cyclooxygenase inhibiting activity. Several derivatives including 4'-chloro, 4'-bromo and 5-chloro, 4'-bromo were more potent than indomethacin in these assays.
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(1947)
