HEMIACETALIC THAPSANE DERIVATIVES FROM THAPSIA VILLOSA VAR. MINOR

Article abstract of DOI:10.1016/0031-9422(86)88028-1

The benzene extract from the roots of Thapsia villosa var. minor afforded six new sesquiterpene esters based on the thapsane skeleton for which the structure (1R,6R,8R,9R)-1,2,2,6,8,9-hexamethylbicyclo<4.3.0>nonane is proposed.Five of these thapsane esters were hemiacetal derivatives esterified at C-1, C-3 or C-8 and the sixth is a dimeric acetal esterified at C-8.The structures of these substances were established on the basis of their spectral data and chemical behaviour, including their transformation into the same compound, 14,15-thapsanolide.Key Word Index- Thapsia villosa var. minor; Umbelliferae; hemiacetalic sesquiterpenes; 14,15-epoxythapsane esters.