Diethylaminosulfur trifluoride-mediated intramolecular cyclization of 2-hydroxycycloalkylureas to fused bicyclic aminooxazoline compounds and evaluation of their biochemical activity against β-secretase-1 (BACE-1)

DOI: 10.1016/j.tetlet.2013.07.136

Source and publish data:

Tetrahedron Letters p. 5802 - 5807 (2013)

Update date:2022-08-05

Topics:

Authors:

Huestis, Malcolm P.

Liu, Wendy

Volgraf, Matthew

Purkey, Hans E.

Yu, Christine

Wang, Weiru

Smith, Darin

Vigers, Guy

Dutcher, Darrin

Hunt, Kevin W.

Siu, Michael

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Article abstract of DOI:10.1016/j.tetlet.2013.07.136

A series of unique bicyclic aminooxazolines were synthesized and found to exhibit micromolar inhibition of β-secretase-1 (BACE-1). The aminooxazolines were procured by an intramolecular diethylaminosulfur trifluoride (DAST)-mediated ring closure of a benz

Full text of DOI:10.1016/j.tetlet.2013.07.136

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