SINGLE-STEP SYNTHESIS OF KYOTORPHIN IN FROZEN SOLUTIONS BY CHYMOTRYPSIN

DOI: 10.1016/S0957-4166(00)80359-6

Source and publish data:

Tetrahedron Asymmetry p. 1559 - 1564 (1993)

Update date:2022-08-04

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Authors:

Meos, Helle

Tougu, Vello

Haga, Mati

Aaviksaar, Aavo

Schuster, Matthias

Jakubke, Hans-Dieter

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Article abstract of DOI:10.1016/S0957-4166(00)80359-6

A novel method of Kyotorphin (H-Tyr-Arg-OH) synthesis without protecting and deprotecting procedures is described - α-chymotrypsin-catalyzed aminolysis of H-Tyr-OEt by H-Arg-OH in frozen mixtures.In this one step process yields of the peptide product above 80percent have been obtained.

Full text of DOI:10.1016/S0957-4166(00)80359-6

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