Tetrahedron Asymmetry p. 1559 - 1564 (1993)
Update date:2022-08-04
Topics:
Meos, Helle
Tougu, Vello
Haga, Mati
Aaviksaar, Aavo
Schuster, Matthias
Jakubke, Hans-Dieter
A novel method of Kyotorphin (H-Tyr-Arg-OH) synthesis without protecting and deprotecting procedures is described - α-chymotrypsin-catalyzed aminolysis of H-Tyr-OEt by H-Arg-OH in frozen mixtures.In this one step process yields of the peptide product above 80percent have been obtained.
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Doi:10.1039/d0md00058b
(2020)Doi:10.1021/jo00197a058
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