Total Synthesis of the Squalene Synthase Inhibitor Zaragozic Acid C by a Carbonyl Ylide Cycloaddition Strategy

DOI: 10.1002/anie.200352629

Source and publish data:

Angewandte Chemie - International Edition p. 5351 - 5355 (2003)

Update date:2022-08-04

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Authors:

Nakamura, Seiichi

Hirata, Yuuki

Kurosaki, Takahiro

Anada, Masahiro

Kataoka, Osamu

Kitagaki, Shinji

Hashimoto, Shunichi

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Article abstract of DOI:10.1002/anie.200352629

Ketal isomers avoided. The unique 2,8-dioxabicyclo[3.2.1 ]octane core of zaragozic acid C (1) was constructed in a Rh-catalyzed 1,3-dipolar cycloaddition of an alkyne to an ester carbonyl ylide. Another feature of this improved synthesis is the constructi

Full text of DOI:10.1002/anie.200352629

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