Journal of Organic Chemistry p. 224 - 228 (1989)
Update date:2022-08-03
Topics:
Rigby, James H.
Balasubramanian, N.
A method for synthesis of highly substituted 2(1H)-pyridones is reported.Vinyl isocyanates, prepared from the corresponding α,β-unsaturated carboxylic acids, undergo cyclization with various enamines to furnish six-membered heterocycles.The methodology is exemplified by numerous examples.Application of this strategy is further illustrated by the synthesis of several aza steroid analogues.
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