C(2)-Methylation Abolishes DA1 Dopamine Agonist Activity of 2-Amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene (6,7-ADTN): Steric Intolerance by the Receptor

Article abstract of DOI:10.1021/jm00378a029

The synthesis of 2-amino-2-methyl-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene is reported.This compound did not produce vasodilation in the dog renal artery and was inactive as a DA₁-type dopamine agonist.This is in contrast to the 2-nonmethyla