Bioorganic and Medicinal Chemistry Letters p. 57 - 62 (2007)
Update date:2022-08-05
Topics:
Pissarnitski, Dmitri A.
Asberom, Theodros
Bara, Thomas A.
Buevich, Alex V.
Clader, John W.
Greenlee, William J.
Guzik, Henry S.
Josien, Hubert B.
Li, Wei
McEwan, Michael
McKittrick, Brian A.
Nechuta, Terry L.
Parker, Eric M.
Sinning, Lisa
Smith, Elizabeth M.
Song, Lixin
Vaccaro, Henry A.
Voigt, Johannes H.
Zhang, Lili
Zhang, Qi
Zhao, Zhiqiang
A novel piperidine series of γ-secretase inhibitors, potentially useful for the treatment of Alzheimer's disease, is disclosed. SAR investigation revealed the requirement for cis-stereochemistry of the substituents attached to the core, which resulted in
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