FACILE SYNTHESIS AND CONVERSION OF MAIN SKELETON OF ASPIROCHLORIN TO 3-AMINOCOUMARIN DERIVATIVES

Article abstract of DOI:10.1246/cl.1984.1301

The condensation of 1,4-diacetyl-2,5-piperazinedione with salicylaldehyde gave 1-acetyl-(Z)-3-salicylidene-2,5-piperazinedione and 3-(N-acetylglycyl)aminocoumarin by ca. 1 : 1 ratio.The former was readily converted with t-BuOCl into spiro<3H-benzofuran-2,3'-(2',5'-dioxo)-piperazine> derivative which has a main skeleton of aspirochlorin.