Chemistry and biodiversity p. 1170 - 1177 (2009)
Update date:2022-08-02
Topics:
Mua, Yan-Ling
Xie, Yan-Ying
Zhou, Ling
Zhong, Ying
Liu, Lu
Bai, Hong
Wang, Yuan-Shu
Zhang, Xiu-Mei
'Methylamine irisolidone' (=5,7-dihydroxy-6-methoxy-3-(4-methoxyphenyl)-8- [(methylamino)-methyl]-4H-[1]benzopyran-4-one), a new compound, is a structurally modified kakkalide with good water solubility. In this study, we investigated its effect on hypoxia/reoxygenation (H/R) injury in cultured rat cardiac myocytes. The results showed that methylamine irisolidone could significantly inhibit lactate dehydrogenase (LDH) release, enhance the mitochondrial membrane potential, decrease intracellular calcium (Ca 2+ ) associated with the attenuation of reactive oxygen species (ROS) generation, reduce contents of malondialdehyde (MDA), and increase the activity of superoxide dismutase (SOD) after H/R in a dose-dependent manner. The present study demonstrated that methylamine irisolidone can directly protect cardiomyocytes against H/R injury, primarily as a result of reduction of the intracellular Ca2+ overload coincident with an attenuation of ROS generation and ROSmediated lipid peroxidation, which may contribute to the preservation of mitochondrion function and antioxidant against H/R injury.
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