α-Acylamino Radical Cyclizations: Syntheses of Isoretronecanol

DOI: 10.1021/ja00338a034

Source and publish data:

Journal of the American Chemical Society p. 8209 - 8217 (1984)

Update date:2022-08-05

Topics:

Authors:

Hart, David J.

Tsai, Yeun-Min

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Article abstract of DOI:10.1021/ja00338a034

α-Acylamino radicals 1-3 can be generated by tri-n-butyltin radical mediated cleavage of a carbon-sulfur bond.These radicals cyclize with good regio- and stereoselectivity to afford pyrrolizidinones.Cyclization products 12a and 23a were converted to the alkaloid isoretronecanol (4).

Full text of DOI:10.1021/ja00338a034

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