AN ASYMMETRIC SYNTHESIS OF GLYCEROL DERIVATIVES BY THE ENANTIOSELECTIVE ACYLATION OF PROCHIRAL GLYCEROL

Article abstract of DOI:10.1246/cl.1984.949

Optically active glycerol derivatives are obtained in up to 84percent e.e. by the selective acylation of the tin(II) alkoxides generated from 2-O-arylsulfonylglycerols and 1,1'-dimethylstannocene or (mehthylcyclopentadienyl)tin(II) chloride by the use of a chiral diamine derived from (S)-proline as a ligand.