Diastereoselective reduction of bicyclic β-enamino carbonyl piperidines - Application to the total synthesis of (-)-deoxocassine

Article abstract of DOI:10.1002/ejoc.200600777

The chemo- and diastereoselective reduction of chiral piperidine β-enamino esters 4 and 6 and β-enamino ketones 5 and 7 was studied and found to afford 2,3- or 2,3,6-substituted piperidines. This approach was successfully applied to the total synthesis of