EFFICIENT SYNTHESIS OF SECONDARY CARBOXAMIDES WITH Ω-SUBSTITUTED ETHYL AND PROPYL GROUPS ON NITROGEN ATOM BY NUCLEOPHILIC RING OPENING OF CYCLIC IMIDATES

Article abstract of DOI:10.1246/cl.1984.1243

An efficient synthesis of secondary carboxamides carrying ω-substituted ethyl and propyl groups on nitrogen atom has been developed which highlights nucleophilic ring opening of 2-methyl-2-oxazoline, 2-methyl-2-oxazine, and their derivatives with (CH3)3SiX and HX (X=Cl, N3, SeC6H5, SC6H5) type reagents.