HYDROLYSIS OF CARBOXYLATE AND PHOSPHATE ESTER USING MONOPYRIDINIUM OXIMES
577
the micellar medium. It can be concluded that the reac-
tivation potency of oxime depends not only on its struc-
ture but also on the kind of substrate used. Cationic mi-
celles showed a tremendous enhancement in the rate of
spontaneous hydrolysis of esters and assisted the rate of
reaction. The observed rate constants were found to in-
crease with increasing surfactant concentration, which
further decreases at a higher surfactant concentration,
showing the nature of micellar-catalyzed reactions. 2-
PAM was found to be the most reactive among all the
investigatedoximesfor thehydrolysis at C O, whereas
4-PAM was most effective oxime for the hydrolysis at
the P O center. Monopyridinium oximes are a par-
ticularly appealing class of α-nucleophiles to examine
since they have pKa values in the range 7–10, which
makes them ideal candidates for decontamination in
the environment, but their structural requirements still
need to be explored. Results of this investigation will
enrich our understanding about reactivators of AChE
and their action and a promising role in detoxification
purposes. Most significantly, results of this investiga-
tion are useful in developing an effective mechanism
for the degradation of chemical and biological warfare
agents under mild conditions.
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International Journal of Chemical Kinetics DOI 10.1002/kin