SYNTHESIS OF α-AMINOKETONES VIA SELECTIVE REDUCTION OF ACYL CYANIDES

DOI: 10.1016/S0040-4039(01)81341-1

Source and publish data:

Tetrahedron Letters p. 2977 - 2980 (1984)

Update date:2022-08-03

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Authors:

Pfaltz, Andreas

Anwar, Saeed

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Article abstract of DOI:10.1016/S0040-4039(01)81341-1

Reduction of acyl cyanides with zinc in acetic acid in the presence of excess acetic anhydride leads to N-acetyl-α-aminoketones in good yields.An efficient three-step synthesis of 5-aminolevulinic acid by this method is described.

Full text of DOI:10.1016/S0040-4039(01)81341-1

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