A Study on the Double Mannich Reaction with 1,3-Diphenylacetone

Article abstract of DOI:10.1007/BF00799166

Double Mannich reaction of the title compound 1 with morpholine acetate in ethanol gave the symmetrical bis-base 2, whereas such reaction in acetic acid afforded the vinyl-ketonic base 3.Reactions of 3 with morpholine, piperidine, thiophenol and dimethyl phosphite were investigated.Mannich reaction of 2 with primary amines gave di-basically substituted γ-piperidones 6a-b.Compound 1 reacts with ethylenediamine and formaldehyde to give the diazatricyclic system 7. - Keywords: Symmetrical bis-Mannich bases; Bis(morpholinomethyl-γ-piperidones; 3,6-Diazatricyclo<4.3.1.1 ^3,8>undecanone; Nitrogen heterocycles