Exceptional stereoselectivity in the synthesis of 1,3,4-trisubstituted 4-carboxy β-lactam derivatives from amino acids

Article abstract of DOI:10.1021/ol070533d

Equation presented The base-promoted cyclization of optically pure N-(p-methoxybenzyl)-N-(2-chloro)propionyl amino acid derivatives resulted in a diastereo- and enantioselective approach to valuable 1,3,4,4-tetrasubstituted β-lactams. The stereochemical outcome of the reaction is exclusively governed by the configuration of the N-(2-chloro)propionyl moiety.