Chemistry of Heterocyclic Compounds p. 924 - 927 (1984)
Update date:2022-08-04
Topics:
Priimenko, B.A.
Romanenko, N.I.
Klyuev, N.A.
Fedulova, I.V.
Gnatov, N.I.
Garmash, S.N.
The reactions of nitration and bromination of 3-methylxanthine were studied.Heating 3-methyl-8-nitroxanthine with con.HCl and HBr leads to a replacement of the nitro group by a halogen atom.The alkylation of 8-haloxanthines by alkyl halides were studied.It was shown that boiling 7-substituted 3-methyl-8-bromoxanthine derivatilves with POCl3 and PCl5 leads to the formation of 2,6,8-trichloro-7-alkylpurines.The structure of synthetized compounds was confirmed by counter synthesis, the data of elementary analysis, and mass spectrometry.
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