Chemical and Pharmaceutical Bulletin p. 616 - 625 (1995)
Update date:2022-08-04
Topics:
Tawada
Natsugari
Ishikawa
Sugiyama
Ikeda
Meguro
Novel 3-ureido derivatives of 4-phenylcoumarin and 4-phenyl-2-quinolone were synthesized and evaluated for acyl-CoA: cholesterol acyltransferase (ACAT)-inhibitory activity. These derivatives inhibited rat intestinal ACAT with IC50 values at the 10-8 to 10-9 M level and were found to normalize plasma cholesterol levels in cholesterol-fed rats when administered as dietary admixtures.
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