Welcome to LookChem.com Sign In|Join Free

Article Doi

Synthesis of 3-ureido derivatives of coumarin and 2-quinolone as potent Acyl-CoA: Cholesterol acyltransferase inhibitors

DOI: 10.1248/cpb.43.616

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 616 - 625 (1995)

Update date:2022-08-04

Topics:

Authors:

TawadaTawada

NatsugariNatsugari

IshikawaIshikawa

SugiyamaSugiyama

IkedaIkeda

MeguroMeguro

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1248/cpb.43.616

Novel 3-ureido derivatives of 4-phenylcoumarin and 4-phenyl-2-quinolone were synthesized and evaluated for acyl-CoA: cholesterol acyltransferase (ACAT)-inhibitory activity. These derivatives inhibited rat intestinal ACAT with IC50 values at the 10-8 to 10-9 M level and were found to normalize plasma cholesterol levels in cholesterol-fed rats when administered as dietary admixtures.

View More

Full text of DOI:10.1248/cpb.43.616

NII-Electronic Library Service  
NII-Electronic Library Service  
NII-Electronic Library Service  
NII-Electronic Library Service  
NII-Electronic Library Service  
NII-Electronic Library Service  
NII-Electronic Library Service  
NII-Electronic Library Service  
NII-Electronic Library Service  
NII-Electronic Library Service  

Products guided by the article

Product name:2-Methyl-benzoic acid 3-chloro-4-methyl-phenyl ester

Cas No:940109-72-8

940109-72-8

R&D Labs maybe for 940109-72-8

Relevant to this article

Hot Product