Total Synthesis of (-)-Grahamimycin A1

Article abstract of DOI:10.1021/jo00204a009

A total synthesis of the novel antibiotic (-)-grahamimycin A₁ (1) is described.The macrocycle 1 was prepared from the convergence of 5(R)-hydroxy-2(E)-hexanoate 2 and (R)-7-octynoic acid 3, both of which were readiy attainable from (R)-methylox