Bioorganic and Medicinal Chemistry Letters p. 4794 - 4797 (2008)
Update date:2022-08-05
Topics:
Scott, David A.
Aquila, Brian M.
Bebernitz, Geraldine A.
Cook, Donald J.
Dakin, Les A.
Deegan, Tracy L.
Hattersley, Maureen M.
Ioannidis, Stephanos
Lyne, Paul D.
Omer, Charles A.
Ye, Minwei
Zheng, XiaoLan
The bisamide class of kinase inhibitors was identified as being active against CSF-1R. The synthesis and SAR of pyridyl and thiazolyl bisamides are reported, along with the pharmacokinetic properties and in vivo activity of selected examples.
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