
Journal of Organic Chemistry p. 420 - 422 (1985)
Update date:2022-08-02
Topics:
Adams, Curtis E.
Walker, Frederick J.
Sharpless, K. Barry
A total synthesis of (-)-swainsonine in 21 steps and 6.6percent overall yield starting from trans-1,4-dichloro-2-butene and N-benzyl-p-toluenesulfonamide is described.The synthesis employs the methodology of the Masamune/Sharpless approach to polyhydroxylated natural products.
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