Enantioselective Synthesis of Swainsonine, a Trihydroxylated Indolizidine Alkaloid

DOI: 10.1021/jo00203a039

Source and publish data:

Journal of Organic Chemistry p. 420 - 422 (1985)

Update date:2022-08-02

Topics:

Authors:

Adams, Curtis E.

Walker, Frederick J.

Sharpless, K. Barry

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Article abstract of DOI:10.1021/jo00203a039

A total synthesis of (-)-swainsonine in 21 steps and 6.6percent overall yield starting from trans-1,4-dichloro-2-butene and N-benzyl-p-toluenesulfonamide is described.The synthesis employs the methodology of the Masamune/Sharpless approach to polyhydroxylated natural products.

Full text of DOI:10.1021/jo00203a039

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