Highly Diastereofacial Selective Addition of Nucleophiles to 2-Alkyl-3-trimethylsilylalk-3-enyl Carbonyl Compounds. Stereoselective Preparation of β-Methylhomoallyl Alcohols and β-Hydroxy-α-methyl Ketones

DOI: 10.1039/c39840001130

Source and publish data:

Journal of the Chemical Society. Chemical communications p. 1130 - 1132 (1984)

Update date:2022-08-04

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Authors:

Sato, Fumie

Kusakabe, Masato

Kobayashi, Yuichi

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Article abstract of DOI:10.1039/c39840001130

Nucleophiles react with 2-alkyl-3-trimethylsilylalk-3-enyl carbonyl compounds to afford 'Cram' products with high diastereoselectivity; this allows the stereoselective preparation of β-methylhomoallyl alcohols and β-hydroxy-α-methyl ketones.

Full text of DOI:10.1039/c39840001130

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