Synthetic Communications p. 1709 - 1714 (2007)
Update date:2022-08-03
Topics:
Jursic, Branko S.
Sagiraju, Sarada
Ancalade, Dustin K.
Clark, Traneil
Stevens, Edwin D.
An efficient two-step synthetic procedure for the preparation of numerous variations of N-protected α,β-unsaturated α-amino acids and their corresponding esters from N-protected glycine and either aliphatic or aromatic aldehydes was developed. The reaction involved cyclization of the N-protected glycine into oxazolone, condensation with the aldehyde, and ring opening with a base. Copyright Taylor & Francis Group, LLC.
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(2007)