Archiv der Pharmazie p. 264 - 267 (2007)
Update date:2022-08-04
Topics:
Waisser, Karel
Matyk, Josef
Divisova, Hana
Husakova, Petra
Kunes, Jiri
Klimesova, Vera
Palat, Karel
Kaustova, Jarmila
Based on our previous studies, 21 new halogenated 3-(4-alkylphenyl)-1,3- benzoxazine-2,4-(3H)-diones were synthesized by the reaction of salicylanilides and methyl-chloroformate. All compounds were screened in vitro against three different strains of mycobacterium, and Free-Wilson method was used to establish structure-activity relationships. 6-Bromo-3-(4-butylphenyl)-1,3-benzoxazine-2, 4-(3H)-dione 3b proved to be the most active compound of the series.
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Doi:10.1016/j.tet.2012.06.063
(2012)Doi:10.1016/j.tetlet.2007.04.133
(2007)Doi:10.1016/j.tetlet.2007.05.016
(2007)Doi:10.1016/S0040-4039(01)91276-6
(1984)Doi:10.1016/j.tet.2007.02.068
(2007)Doi:10.1039/a908447i
(2000)
