DNA binding and catalytic properties of positively charged corroles

Article abstract of DOI:10.1002/anie.200700757

DNA likes corroles and peroxynitrite doesn't: The water-soluble manganese corrole (crystal structure shown) is a much better catalyst than the analogous porphyrin for decomposition of peroxynitrite (HOONO). The interactions of the two complexes with DNA are also significantly different. These findings suggest that positively charged corroles may be useful for therapeutic approaches. (Figure Presented)