Development of piperazine-tethered heterodimers as potent antimalarials against chloroquine-resistant P. falciparum strains. Synthesis and molecular modeling

DOI: 10.1016/j.bmcl.2007.04.077

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 3535 - 3539 (2007)

Update date:2022-09-26

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Authors:

Gemma, Sandra

Kukreja, Gagan

Campiani, Giuseppe

Butini, Stefania

Bernetti, Matteo

Joshi, Bhupendra P.

Savini, Luisa

Basilico, Nicoletta

Taramelli, Donatella

Yardley, Vanessa

Bertamino, Alessia

Novellino, Ettore

Persico, Marco

Catalanotti, Bruno

Fattorusso, Caterina

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Article abstract of DOI:10.1016/j.bmcl.2007.04.077

The design, synthesis, and antiplasmodial activity of antimalarial heterodimers based on the 1,4-bis(3-aminopropyl)piperazine linker is reported. In this series key structural elements derived from quinoline antimalarials were coupled to fragments capable

Full text of DOI:10.1016/j.bmcl.2007.04.077

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