Studies on the macrolides from marine dinoflagellate Amphidinium sp.: structures of amphidinolides R and S and a succinate feeding experiment

Article abstract of DOI:10.1016/S0040-4020(97)00473-0

Two new cytotoxic macrolides, amphidinolides R (1) and S (2), were isolated from the cultured marine dinoflagellate Amphidinium sp. and their structures including absolute configuration were elucidated on the basis of spectroscopic data as well as chemical experiments. In a feeding experiment of ¹³C-labeled succinic acid into a culture of Amphidinium sp., no enrichment of the ¹³C NMR signal intensity of any carbon of amphidinolide J (3), the most abundant macrolide in this dinoflagellate, was observed.