An Efficient Synthesis of α,β-Unsaturated Aldehydes by a Four-Carbon Unit Extension of Grignard Reagents

Article abstract of DOI:10.1002/hlca.19840670607

Copper-catalyzed addition of organomagnesium halides to 2-(2,2-diethoxy-ethyl)oxirane (1) affords aldol acetals 2 which upon acid treatment undergo hydrolysis and dehydration to give α,β-unsaturated aldehydes 7 with high yields.