Synthesis of bridged catechol-homocysteine derivatives as potential inhibitors of catechol O-methyltransferase

Article abstract of DOI:10.1002/jps.2600730912

Catechol derivatives, covalently joined to homocysteine by sulfide or sulfonium linkages, were synthesized as potential catechol O-methyl-transferase inhibitors which might bridge the enzymatic binding sites for the catechol substrate and the amino acid p