Stereoselective metabolism of conformational analogues of warfarin by β-naphthoflavone-inducible cytochrome P-450

DOI: 10.1021/jm00382a021

Source and publish data:

Journal of Medicinal Chemistry p. 503 - 506 (1985)

Update date:2022-07-30

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Authors:

Heimark Heimark

Trager Trager

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Article abstract of DOI:10.1021/jm00382a021

Previous studies have shown that the structurally related oral anticoagulants warfarin and phenprocoumon are regioselectively hydroxylated in the 6- and 8-positions by hepatic microsomes obtained from 3-methylcholanthrene (3-MC) or β-naphthofalvone (BNF)

Full text of DOI:10.1021/jm00382a021

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