Peptide backbone-to-backbone cyclisation as an avenue to β-turn mimics

Article abstract of DOI:10.1016/0040-4039(94)88485-4

1,3-Dipolar cycloaddition of the nitrone functionality of 13 and the alkene functionality of 8 yields the backbone-to-backbone cyclised peptides 14-16. The conformation of these structures is such that they are p-turn mimics. They differ in their C3/C5 stereochemistry with discrete conformational differences.