Ibotenic Acid Analogues. Synthesis, Molecular Flexibility, and in Vitro Activity of Agonists and Antagonists at Central Glutamic Acid Receptors

Article abstract of DOI:10.1021/jm50001a022

The syntheses of (RS)-α-amino-3-hydroxy-5-tert-butyl-4-isoxazolepropionic acid (9, ATPA), (α-RS,β-RS)-α-amino-β-methyl-3-hydroxy-5-isoxazolepropionic acid (8), (RS)-α-amino-3-hydroxy-5-isoxazolebutyric acid (15a), and (RS)-α-amino-3-hydroxy-5-isoxazoleval