Spirocyclopropane compounds. IV. Synthesis of 5-acetylspiro[benzofuran-2(3H),1'-cyclopropan]-3-one-related compounds for evaluation as gastric antisecretory and antiulcer agents

DOI: 10.1248/cpb.32.3551

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 3551 - 3560 (1984)

Update date:2022-07-30

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Authors:

Watanabe

Kawada Kawada

Hirata Hirata

Maki Maki

Imada Imada

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Article abstract of DOI:10.1248/cpb.32.3551

5-Acetylspiro[benzofuran-2(3H),1'-cyclopropan]-3-one (1a) shows potent gastric antisecretory and antiulcer activities in rats. In an attempt to improve the pharmacological profile of 1a, we synthesized positional isomers, as well as the prenyloxy and oxim

Full text of DOI:10.1248/cpb.32.3551

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