
Chemistry of Natural Compounds p. 601 - 605 (1984)
Update date:2022-07-29
Topics:
Veiko, V. P.
Oretskaya, T. S.
Volkov, E. M.
Metelev, V. G.
Romanova, E. A.
Potapov, V. K.
Two methods for synthesizing oligodeoxyribonucleotides containing 3'-terminal phosphate groups have been developed.The first consists in the synthesis and the introduction into the oligonucleotides of a block containing a 3'-terminal bis(2-cyanoethyl) phosphate group and the second in the use of the transesterification reaction of oligonucleotides with 2-cyanoethanol in the presence of cesium fluoride.Both methods permit the fairly effective synthesis of oligodeoxyribonucleotide 3'-phosphates.
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