Design and synthesis of potent inhibitors of cholesteryl ester transfer protein (CETP) exploiting a 1,2,3,4-tetrahydroquinoline platform

DOI: 10.1016/j.bmcl.2009.03.051

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2456 - 2460 (2009)

Update date:2022-09-26

Topics:

Authors:

Rano, Thomas A.

Sieber-McMaster, Ellen

Pelton, Patricia D.

Yang, Maria

Demarest, Keith T.

Kuo, Gee-Hong

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Article abstract of DOI:10.1016/j.bmcl.2009.03.051

Tetrahydroquinoline A is a potent inhibitor of the cholesterol ester transfer protein (CETP), a target for the treatment of low HDL-C and atherosclerosis. Low HDL-C has been identified as a key risk factor for cardiovascular disease in addition to high LD

Full text of DOI:10.1016/j.bmcl.2009.03.051

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