Synthesis, in Vitro 3H>Prazosin Displacement, and in Vivo Activity of 3-Aryl-4,5,6,7-tetrahydropyrazolopyridines, a New Class of Antihypertensive Agents

DOI: 10.1021/jm00145a015

Source and publish data:

Journal of Medicinal Chemistry p. 934 - 940 (1985)

Update date:2022-08-04

Topics:

Authors:

Winters, Giorgio

Sala, Alberto

Barone, Domenico

Baldoli, Emiliana

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00145a015

A series of a new 3-aryl-4,5,6,7-tetrahydropyrazolo<4,3-c>pyridines was synthesized and screened for in vitro <³H>prazosin displacement activity.The results correlated well with their antihypertensive activity in spontaneous hypertensive rats.

Full text of DOI:10.1021/jm00145a015

Products guided by the article

Product name:5-Methyl-3-p-tolyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine

Cas No:95936-08-6

R&D Labs maybe for 95936-08-6

AURORA CHEMICAL CO., LTD

Contact:86-532-68629711 13780605697

Address:NO 220 YANAN 3 ROAD,(POST ADMINISTRATION BUILDING),QINGDAO,CHINA
Shandong Dayi Chemical Co., Ltd.

website:http://www.dayi.com.cn

Contact:+86- 535-7388728. 15306386031

Address:No 1 Danya west road, Laiyang City, Shandong province
Shandong Jusage Technology Co.,Ltd.

Contact:86-13406130167

Address:No.20,North Ride No.9 Road, Guangrao Economic Development Zone, Shandong Province
Shandong Bolode Bio-Technology Co., LTD

Contact:+86-0531-58966870

Address:136 Jingyi Road,Huaiyin District,Jinan,Shandong,China
Weifang Ocean Trading Co., Ltd.

Contact:+86-536-2081155

Address:Room2606, Yuqing Building, 518#, Yuquan Road, High-tech Development Zone, Weifang City, Shandong Province, China

Relevant to this article

Chemistry of 4-alkylaryloxenium ion "precursors": Sound and fury signifying something?

Doi:10.1021/jo701853e
(2007)
Asymmetric formation of allylic amines with N-substituted quaternary stereocenters by Pd^II-catalyzed aza-Claisen rearrangements

Doi:10.1002/anie.200702086
(2007)
Total synthesis of (±)-communesin F

Doi:10.1021/ja075705g
(2007)
Diastereoselective Michael initiated ring closure on vinyl sulfone-modified carbohydrates: A stereospecific and general route to α-substituted cyclopropanes

Doi:10.1021/jo701378d
(2007)
'High-surface sodium' as a reducing agent for TiCl 3

Doi:10.1055/s-1995-3854
(1995)
CuCl-catalyzed cleavage of S-triphenylmethyl thioether: a new detritylation method for thio group

Doi:10.1016/j.tetlet.2006.12.090
(2007)

Article Doi