Synthesis, in Vitro 3H>Prazosin Displacement, and in Vivo Activity of 3-Aryl-4,5,6,7-tetrahydropyrazolopyridines, a New Class of Antihypertensive Agents

DOI: 10.1021/jm00145a015

Source and publish data:

Journal of Medicinal Chemistry p. 934 - 940 (1985)

Update date:2022-08-04

Topics:

Authors:

Winters, Giorgio

Sala, Alberto

Barone, Domenico

Baldoli, Emiliana

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Article abstract of DOI:10.1021/jm00145a015

A series of a new 3-aryl-4,5,6,7-tetrahydropyrazolo<4,3-c>pyridines was synthesized and screened for in vitro <³H>prazosin displacement activity.The results correlated well with their antihypertensive activity in spontaneous hypertensive rats.

Full text of DOI:10.1021/jm00145a015

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