A Facile Enantioselective Synthesis of (1R,2R,3S)-1-Amino-2,3-bishydroxymethylcyclobutane Derivatives, A Key Synthetic Intermediate of Carbocyclic Oxetanocins

Article abstract of DOI:10.1016/S0040-4020(01)88715-9

(1R,2R,3S)-1-Amino-2,3-bishydroxymethylcyclobutane derivatives (14, 15) have been synthesized enantioselectively by <2+3> formation of a cyclopentane ring from (-)-dimenthyl succinate and 3-chloro-2-(chloromethyl)-1-propene and the subsequent ring contrac