A Facile Enantioselective Synthesis of (1R,2R,3S)-1-Amino-2,3-bishydroxymethylcyclobutane Derivatives, A Key Synthetic Intermediate of Carbocyclic Oxetanocins

DOI: 10.1016/S0040-4020(01)88715-9

Source and publish data:

Tetrahedron p. 1573 - 1580 (1992)

Update date:2022-08-02

Topics:

Authors:

Izawa, Takao

Ogino, Yoshio

Nishiyama, Shigeru

Yamamura, Shosuke

Kato, Kuniki

Takita, Tomohisa

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Article abstract of DOI:10.1016/S0040-4020(01)88715-9

(1R,2R,3S)-1-Amino-2,3-bishydroxymethylcyclobutane derivatives (14, 15) have been synthesized enantioselectively by <2+3> formation of a cyclopentane ring from (-)-dimenthyl succinate and 3-chloro-2-(chloromethyl)-1-propene and the subsequent ring contrac

Full text of DOI:10.1016/S0040-4020(01)88715-9

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