Opioid agonists and antagonists. 6-desoxy-6-substituted lactone, epoxide, and glycidate ester derivatives of naltrexone and oxymorphone

DOI: 10.1021/jm00145a018

Source and publish data:

Journal of Medicinal Chemistry p. 949 - 957 (1985)

Update date:2022-09-26

Topics:

Authors:

Koolpe Koolpe

Nelson Nelson

Gioannini

Angel Angel

Appelmans

Simon Simon

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Article abstract of DOI:10.1021/jm00145a018

Synthesis and opioid radioreceptor assay data on analogues closely related to 6-desoxy-6-spiro-α-methylene-γ-lactone 5a, a compound with irreversible activity in this assay, are reported. Saturated lactones, endocyclic, α,β-unsaturated γ-lactones, and 6α,

Full text of DOI:10.1021/jm00145a018

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