Journal of Organic Chemistry p. 930 - 938 (2018)
Update date:2022-08-04
Topics:
Tang, Ren-Jin
Milcent, Thierry
Crousse, Benoit
Regioselective halogenation of arenes and heterocycles with N-halosuccinimides in fluorinated alcohols is disclosed. Under mild condition reactions, a wide diversity of halogenated arenes are obtained in good yields with high regioselectivity. Additionally, the versatility of the method is demonstrated by the development of one-pot sequential halogenation and halogenation-Suzuki cross-coupling reactions.
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