Regioselectivity in lithiation of t-butyldimethylsiloxy-3, 5-dimethoxybenzene. A synthesis of the trimethyl ether of sophoraflavanone A

Article abstract of DOI:10.1016/S0040-4039(00)61859-2

Selective metallation by inhibiting the directive effect of an oxygen substituent leads to selective substitution of a trioxygenated benzene and a five step synthesis of the titled potentially anti-fungal natural product.