A LIGNAN FROM LONICERA HYPOLEUCA

Article abstract of DOI:10.1016/S0031-9422(00)80792-X

Key Word Index - Lonicera hypoleuca; Caprifoliaceae; lignan; 4-hydroxy-2,6-di(4'-hydroxy-3'-methoxy)phenyl-3,7-dioxabicyclo(3.3.0)octane; n-10-nonacosanol; scopoletin; syringic acid; sitosterol; β-sitosterol-β-D-glucoside; spasmolytic activity. - A new lignan characterised as (-)-4-hydroxy-2,6-di(4'-hydroxy-3'-methoxy)phenyl-3,7-dioxabicyclo(3.3.0)ocatane along with n-10-nonacosanol, scopoletin, syringic acid, β-sitosterol and its glucoside, has been isolated from the aerial parts of Lonicera hypoleuca.The stereochemistry of the lignan hasn been established by itsspectroscopic analysis and those of its derivatives, and by its conversion to (+)-pinoresinol. β-Sitosterol-β-D-glucoside displayed good spasmolitic activity.