
Journal of Organic Chemistry p. 2804 - 2805 (1985)
Update date:2022-07-29
Topics:
Wade, Peter A.
Price, David T.
McCauley, John P.
Carroll, Patrick J.
The reactions of organolithium and Grignard reagents with 3-acyl-4,5-disubstituted-isoxazolines to produce tertiary alcohols show high but opposite diastereoselectivity; competitive pathways involving attack on s-trans and metal-chelated s-cis conformations of the O=CC=N system are proposed.
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Doi:10.1021/jo00217a040
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